The Upper East Side runs from 59th Street (the bottom of Central Park) to 96th Street, between Fifth Avenue and the East River. It is, by any measure, one of the wealthiest residential neighborhoods in the United States — the blocks between 60th and 86th Streets on Park Avenue and Fifth Avenue represent some of the most expensive real estate on the planet. Hotels here operate accordingly, and the best of them are exceptional.
The neighborhood's relationship with the Metropolitan Museum of Art defines much of its appeal for visitors. The museum's Fifth Avenue entrance at 82nd Street anchors an extraordinary cultural corridor — within walking distance, you can visit the Guggenheim (89th and Fifth), the Neue Galerie (86th and Fifth), the Frick Collection (70th and Fifth), the Cooper Hewitt (91st and Fifth), and the American Museum of Natural History (Central Park West — technically the Upper West Side, but easily walkable). For museum-focused travelers, the Upper East Side is the most logistically convenient neighborhood in New York.
Madison Avenue between 57th and 86th Streets is the fashion and gallery corridor — Chanel, Hermès, Brunello Cucinelli, and Ralph Lauren all have flagship stores, interspersed with contemporary art galleries that rival the best of Chelsea. For shopping tourists, this strip is unrivaled anywhere in the city.
The restaurant scene on the Upper East Side has historically lagged behind downtown neighborhoods but has strengthened considerably. Daniel Boulud's flagship Daniel on East 65th Street remains one of the great formal dining rooms in America. The German-Austro-Hungarian enclave of Yorkville (86th Street east of Lexington) has several excellent old-school restaurants. Café Boulud in the Surrey Hotel and JG Melon on Third Avenue are both neighborhood institutions worth planning around.