New York rewards strategic hotel placement more than almost any city on earth. The island of Manhattan is narrow enough that east-west distance is trivial, but north-south distance matters enormously. A hotel in Midtown puts you within a 15-minute walk of the Empire State Building, Rockefeller Center, Times Square, and the entrance to Central Park. Move downtown and you're closer to the Brooklyn Bridge, the 9/11 Memorial, and the Village's restaurant scene.
The ideal sightseeing base for first-timers is the band between 34th Street and 59th Street — Midtown, essentially. From here, you can walk to most major landmarks, and the subway connections (at Times Square, Herald Square, and Grand Central) are the best in the system. Second-timers might prefer the West Village or Lower East Side, where the sightseeing gives way to neighbourhood immersion.
Don't underestimate the value of a hotel with a view. Watching the city light up from your room at dusk is a sightseeing experience in itself — and several Midtown hotels offer skyline panoramas that rival the observation decks.
One practical note: proximity to a major subway hub matters more than street address. A hotel two blocks from the A/C/E at Penn Station puts all five boroughs within reach.